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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy(myalgic encephalomyelitis/chronic muscle weakness). Our primary hypothesis was that a low dose of LDX (0.20 mcg/kg) or a similar-looking placebo would not result in a clinically meaningful change in the change in muscle mass or strength observed in the two groups as measured by the leg-press test. As the LDX study did not include strength testing, one can't really assess this question directly. However, as previously described, the LDX study involved no strength testing. The research design for this trial was double-blind (1) in design. This was a double-blind, randomized, controlled and double-blind trial. The participants in the LDX group were selected based on a 1-page ad in a large newspaper: "If you're 65 or older and are healthy and you've done no exercise for the past 6 months, LDX is the first thing you must take." As per the original trial, patients were paid in advance for the procedure or pills. The ad also indicated the drug cost: "LDX-500, LDX-400 and LDX-1000 cost $300, $100 and $50, respectively, and LDX-300 costs $100." The drug (LDX) was injected under a general anesthetic (usually ketamine per body part) and administered in an outpatient setting, by a nurse who had a doctorate in palliative care and was experienced with these types of procedures. LDX was prescribed to all 65+ subjects for 5 days beginning on 4 June 2014 and was administered in divided doses. The treatment consisted of LDX injections for 5 days per week. To minimize risks of infection after injection, the needles were not coated with an anti-tubercular antibiotic and it was not possible to disinfect prior surgery. Additionally, both patients and their caregivers completed a detailed self-administered questionnaire to verify compliance with the treatment regime. A total of 50 treatment cycles were carried out, resulting in a final dose of LDX dose of 8.5 mcg daily. The average time to complete the study was 7.8 weeks. During this period the subjects were required to undergo the same strength, muscle and total body strength testing that was conducted during the placebo-controlled trial. In July 2014, after being informed that LDX was effective, 66 out of 70 patients received their treatments without any adverse events other than a little bit of pain in the Related Article: